H?gh d???? can r??ult ?n v?r? h?gh bl??d ?r???ur? ?r b?d? t?m??r?tur?. Eff??t? b?g?n inside of seconds to minutes of u?? and l??t b?tw??n file?v? and n?n?t? m?nut??. It ??n ????l? ?r??? th? bl??d–br??n b?rr??r ?nd m?? result in th? br??kd?wn ?f th? b?rr??r. File?r?tl?, A C????n? R?h?b ?r